MDEAT - a new databionic evaluation and analysis tool to identify the virulence regulon of Listeria monocytogenes as a model system
نویسندگان
چکیده
B Background The pathogenic bacterium Listeria monocytogenes is able to cross the endothelial, placental and blood-brain barrier causing gastritis, meningitis, neonatal death and other diseases in humans. PrfA (Positive regulatory factor A) is the sole regulator of the virulence genes identified in Listeria monocytogenes till date. It regulates genes within the virulence gene cluster (vgc), which harbors prfA itself, plcA, hly, mpl, actA and plcB. PrfA is also known to regulate cell-wall associated internalins (inlA and inlB), secreted internalins (inlC) and activates the transcription of genes involved in hexose phosphate uptake and bile salt hydrolases. We tried to identify additional PrfA regulated genes using a novel bioinformatic approach.
منابع مشابه
The Listeria monocytogenes σB Regulon and Its Virulence-Associated Functions Are Inhibited by a Small Molecule
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